Everything about Nonproteinogenic totally explained
Proteinogenic amino acids, also known as standard, normal, or primary amino acids, are those 20 amino acids that are found in
proteins and that are coded for in the standard
genetic code. Proteinogenic literally means
protein building. Proteinogenic amino acids are assembled into a
polypeptide (the subunit of a protein) through a process known as
translation (the second stage of protein biosynthesis, part of the overall process of
gene expression).
Non-proteinogenic amino acids are either not found in proteins (like
carnitine,
GABA, or
L-DOPA), or not coded for in the standard
genetic code (like
hydroxyproline and
selenomethionine). The latter often result from
posttranslational modification of proteins.
Some non-proteinogenic amino acids, such as
ornithine and
homoserine have clear reasons why organisms have not
evolved to incorporate them into proteins; both of these amino acids will cyclize against the peptide backbone and fragment the protein with relatively short half-lives.
Some non-proteinogenic amino acids are toxic because they can be mistakenly incorporated into proteins, one example is the
arginine analog
canavanine.
Further Information
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